Urinary Titin N-Fragment as a Biomarker of Muscle Atrophy, Intensive Care Unit-Acquired Weakness, and Possible Application for Post-Intensive Care Syndrome

Titin is a giant protein that functions as molecular spring in sarcomeres. interconnects the contraction of actin-containing thin filaments and myosin-containing thick filaments. breaks down to form urinary titin N-fragments, which are measurable urine. Urinary N-fragment was originally reported be useful biomarker diagnosis muscle dystrophy. Recently, has been increasingly gaining attention novel atrophy intensive care unit-acquired weakness critically ill patients, whom loss possible pathophysiology. Furthermore, several studies have also reflected patients with chronic illnesses. It may used predict risk post-intensive syndrome or monitor patients’ condition after hospital discharge for better nutritional rehabilitation management. We provide tips on use this promising syndrome.